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Seryl-tRNA synthetase is not responsible for the evolution of CUG codon reassignment in Candida albicans

O’Sullivan JM, Mihr MJ, Santos MA, Tuite MF Yeast. Wiley Online Library; 2001;18(4):313–22 A number of Candida species translate the standard leucine-CUG codon as serine using a novel ser-tRNA(CAG). This tRNA, which has an unusual anticodon stem-loop structure, has been implicated in the evolution of this codon reassignment. However, such a sense codon reassignment might … Continue reading Seryl-tRNA synthetase is not responsible for the evolution of CUG codon reassignment in Candida albicans



The Candida albicans gene encoding the cytoplasmic leucyl-tRNA synthetase: implications for the evolution of CUG codon reassignment

O’Sullivan JM, Mihr MJ, Santos M, Tuite MF Gene. 2001 Sep 5;275(1):133-40 In a number of Candida species the ‘universal’ leucine codon CUG is decoded as serine. To help understand the evolution of such a codonreassignment we have analyzed the Candida albicans leucyl-tRNA synthetase (CaLeuRS) gene (CaCDC60). The predicted CaLeuRS sequence shows a significant level … Continue reading The Candida albicans gene encoding the cytoplasmic leucyl-tRNA synthetase: implications for the evolution of CUG codon reassignment



Apoptosis induced by environmental stresses and amphotericin B in Candida albicans

Phillips AJ, Sudbery I, Ramsdale M Proc Natl Acad Sci USA. 2003 Nov 25;100(24):14327–32 New antifungal agents are urgently required to combat life-threatening infections caused by opportunistic fungal pathogens like Candida albicans. The manipulation of endogenous fungal programmed cell death responses could provide a basis for future therapies. Here we assess the physiology of death … Continue reading Apoptosis induced by environmental stresses and amphotericin B in Candida albicans



Candida albicans, a distinctive fungal model for cellular aging study

Fu X-H, Meng F-L, Hu Y, Zhou J-Q Aging Cell. 2008 Oct;7(5):746–57 The unicellular eukaryotic organisms represent the popular model systems to understand aging in eukaryotes. Candida albicans, a polymorphic fungus, appears to be another distinctive unicellular aging model in addition to the budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe. The two types … Continue reading Candida albicans, a distinctive fungal model for cellular aging study