Archive

Multidirectional and multizonal tangential migration of GABAergic interneurons in the developing cerebral cortex

Tanaka DH, Maekawa K, Yanagawa Y, Obata K, Murakami F Development. 2006 Jun;133(11):2167–76 Most GABAergic interneurons originate from the basal forebrain and migrate tangentially into the cortex. The migratory pathways and mode of interneuron migration within the developing cerebral cortex, however, previously was largely unknown. Time-lapse imaging and in vivo labelling with glutamate decarboxylase (GAD)67-green … Continue reading Multidirectional and multizonal tangential migration of GABAergic interneurons in the developing cerebral cortex



Hearing preservation after inner ear gene therapy: the effect of vector and surgical approach

Praetorius M, Baker K, Weich CM, Plinkert PK, Staecker H ORL J Otorhinolaryngol Relat Spec. 2003 Jul;65(4):211–4 Over seventy studies have examined the potential of gene therapy in the inner ear. For the most part, they have focused on adenoviral vectors and delivery into the cochlea. Most studies have emphasized looking at the expression of … Continue reading Hearing preservation after inner ear gene therapy: the effect of vector and surgical approach



A mouse model of implantation trauma

Do K, Baker K, Praetorius M, Staecker H International Congress Series. 2004 Nov;1273:167–70. Objective: To develop and validate a mouse model of implantation trauma. Study design: Adult CBA mice were anesthetized and a basal turn cochleostomy created. Using a micromanipulator varying amounts of sterile phosphate-buffered saline were injected into the cochleostomy. The cochleostomy was sealed … Continue reading A mouse model of implantation trauma



Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouse

Praetorius M, Baker K, Brough DE, Plinkert P, Staecker H Hear Res. 2007 May;227(1-2):53–8 Recent studies have demonstrated that delivery of genes to the inner ear can achieve a variety of effects ranging from support of auditory neuron survival to protection and restoration of hair cells, demonstrating the utility of vector based gene delivery. Translation … Continue reading Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouse



Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

Dhungel N, Eleuteri S, Li L-B, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD Neuron. 2015 Jan;85(1):76–87 Yeast/SGA Parkinson’s disease (PD) is a common neurodegenerative disorder. Functional interactions between some PD genes, like PINK1 and parkin, have been identified, … Continue reading Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein