Colony-live —a high-throughput method for measuring microbial colony growth kinetics— reveals diverse growth effects of gene knockouts in Escherichia coli

Takeuchi, R., Tamura, T., Nakayashiki, T., Tanaka, Y., Muto, A., Wanner, B. L., & Mori, H.

BMC Microbiol. 2014; 14: 171.

Precise quantitative growth measurements and detection of small growth changes in high-throughput manner is essential for fundamental studies of bacterial cell. However, an inherent tradeoff for measurement quality in high-throughput methods sacrifices some measurement quality. A key challenge has been how to enhance measurement quality without sacrificing throughput.


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