High Throughput Screening | ROTOR+

Plate a million colonies an hour

Are you looking to find a one in a million hit?

You know it’s likely going to take you months of pipetting 96-well plates to find it.

But with ROTOR+, you should find your hit in just one day¹. Yes really. In fact, there is no more high throughput and precise way to complete a microbial screen, period. Don’t just take our word for it – our customers have more than 10,000 citations to prove it.*

 Based on the total number of citations to publications that mention ROTOR, Singer Instruments.*

Enough said, stop deliberating

Why haven’t you bought this yet?… or read on, why not?
You’ve got time to spare.

ROTOR+ is going to get you your one in a million hit before lunch break.
Sounds too good to be true doesn’t it?

“For scalability and high throughput the ROTOR+ has allowed us to phenotype
thousands of strains, which otherwise would not have been possible.”

Professor Joseph Schacherer
Strasbourg University, co-founder of the 1002 Yeast Genomes Project. 

What is ROTOR+?

ROTOR+ is a precision benchtop robot for easy, ultra-fast manipulation
of high-density microbial arrays. Using sterile ready-to-use replica plating pads,
ROTOR+ reliably supports liquid pinning to and from 96 and 384-well
microtiter plates, and agar pinning at densities of 96, 384, 1536, and even 6144
(that’s a whole yeast knockout library on one plate).

Array yeast, fungi, bacteria and algae. ROTOR+ lets you screen millions
of strains with unparalleled efficiency and reproducibility.

2) Bean GJ, Jaeger PA, Bahr S, Ideker T. Development of ultra-high-density screening tools for microbial “omics”. PLoS One. 2014 Jan 21;9(1):e85177. https://doi.10.1371/journal.pone.0085177

OM(G)-ics!

Trey Ideker and colleagues at the University of San Diego
successfully used ROTOR to plate a mind blowing
24576 individual yeast colonies on a single plate^.2
What’s more they achieved equal or better precision than alternative
methods, revolutionising high throughput screening.

“My lab got a ROTOR 6 years ago and our overall experience has been great. The robot
is very easy to use (any undergrads in the lab have used the robot) and is very dependable
(we actually never had to use our service contract). People at Singer are responsive
and work with the customer to set up different applications. Highly recommend!”

Associate Professor Juan Fuxman
Boston University
Centre for Cancer Systems Biology.

Intuitive Software

The software guides you through every step, providing clear visual cues to prompt any necessary plate swapping. Agar sensing and customisable pinning head movements, including wet and dry mixing options optimise transfer efficiency for your chosen organism or media.

ROTOR+ Applications

1. Library construction.
2. Library maintenance.
3. SGA for genome-wide genetic interactions.
4. Functional genetic screens.
5. Yeast 2-hybrid for protein-protein interactions
6. Drug target discovery.
7. Chemical genetic screens.
8. High content screening.
9. Biofuels strain selection.
10. Strain improvement and engineering.
11. Brewery and fermentation.
12. Random mutagenesis screens.
13. High-throughput streaking.
14. Your next big project…?

“Singer Instruments are a wonderful company that make very high quality tools
(we use them for yeast genetics) and put their customers at the heart of everything they do.
They provide outstanding support, both engineering and application support.
Our Singer ROTOR is a workhorse for the lab that has served us for more than 10 years!”

Professor Liz Miller
University of Dundee,
Division of Molecular, Cell and Developmental Biology