Webinar
Saturation genome editing with CRISPR: A ‘MAGESTIC’ solution for dissecting complex quantitative traits
Join us on Wednesday, October 9th
at 10AM PDT / 1PM EDT / 7PM CEST
Join Kevin Roy, Research Scientist at Stanford University, as he presents the MAGESTIC solution: leveraging homologous DNA repair to perform high-throughput CRISPR screens with a 5-fold increase in genome editing efficiency.
Here’s why you’ll want to join:
- Discover how Kevin and his team are achieving a 5-fold increase in genome editing efficiency.
- Learn how genome-integrated barcodes can precisely track and verify genetic edits.
- See how Kevin optimised his approach with robotics to reach the throughput needed for complex synthetic biology projects.
The solution: Saturation genome editing with MAGESTIC 3.0
By harnessing the combined benefits of several other library-scale guide-donor systems developed in yeast, Dr Kevin Roy and colleagues have created a single “supercharged donor repair system”, proposed to be substantially superior to all previous systems.
Fundamentally, their findings demonstrate how saturation genome editing might be achieved, not just in yeast, but across other species and cell lines.1
Reference
Roy KR, Smith JD, Li S, Vonesch SC, Nguyen M, Burnett WT, Orsley KM, Lee CS, Haber JE, St Onge RP, Steinmetz LM. Dissecting quantitative trait nucleotides by saturation genome editing. bioRxiv [Preprint]. 2024 Feb 2:2024.02.02.577784. doi: 10.1101/2024.02.02.577784. PMID: 38352467; PMCID: PMC10862795.