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The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae.

Quevedo O, Ramos-Pérez C, Petes TD, Machín F. Quevedo O, Ramos-Pérez C, Petes TD, Machín F. Genomic instability is a common feature found in cancer cells. Accordingly, many tumor suppressor genes identified in familiar cancer syndromes are involved in the maintenance of the stability of the genome during every cell division and are commonly referred … Continue reading The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae.



Genetic alteration of UDP‐rhamnose metabolism in Botrytis cinerea leads to accumulation of UDP‐KDG that adversely affects development and pathogenicity

Ma L, Salas O, Bowler K, Oren-Young L, Bar-Peled M, Sharon A Mol Plant Pathol. 2016 Mar 17 Botrytis cinerea is a model plant pathogenic fungus that causes grey mold and rot diseases in a wide range of agriculturally important crops. A previous study identified two enzymes and corresponding genes (bcdh, bcer) that are involved … Continue reading Genetic alteration of UDP‐rhamnose metabolism in Botrytis cinerea leads to accumulation of UDP‐KDG that adversely affects development and pathogenicity



Mitochondrial anchorage and fusion contribute to mitochondrial inheritance and quality control in the budding yeast Saccharomyces cerevisiae

Higuchi-Sanabria R, Charalel JK, Viana MP, Garcia EJ, Sing CN, Koenigsberg A, Swayne TC, Vevea JD, Boldogh IR, Rafelski SM, Pon LA. Mol Biol Cell. 2016 Mar 1;27(5):776-87. Higher-functioning mitochondria that are more reduced and have less ROS are anchored in the yeast bud tip by the Dsl1-family protein Mmr1p. Here we report a role … Continue reading Mitochondrial anchorage and fusion contribute to mitochondrial inheritance and quality control in the budding yeast Saccharomyces cerevisiae



Meiotic and Mitotic Phenotypes Conferred by the blm1-1 Mutation in Saccharomyces cerevisiae and MSH4 Suppression of the Bleomycin Hypersusceptibility

Anyatonwu G, Garcia E, Pramanik A, Powell M, Moore CW Int. J. Mol. Sci. 2003, 4(1), 1-12 Oxidative damage can lead to a number of diseases, and can be fatal. The blm1-1 mutation of Saccharomyces cerevisiae confers hypersusceptibility to lethal effects of the oxidative, anticancer and antifungal agent, bleomycin. For the current report, additional defects … Continue reading Meiotic and Mitotic Phenotypes Conferred by the blm1-1 Mutation in Saccharomyces cerevisiae and MSH4 Suppression of the Bleomycin Hypersusceptibility



Inactivation of Ku-mediated end joining suppresses mec1Delta lethality by depleting the ribonucleotide reductase inhibitor Sml1 through a pathway controlled by Tel1 kinase and the Mre11 complex

Corda Y, Lee SE, Guillot S, Walther A, Sollier J, Arbel-Eden A, Haber JE, Géli V Mol Cell Biol. 2005 Dec;25(23):10652–64 RAD53 and MEC1 are essential Saccharomyces cerevisiae genes required for the DNA replication and DNA damage checkpoint responses. Theirlethality can be suppressed by increasing the intracellular pool of deoxynucleotide triphosphates. We report that deletion … Continue reading Inactivation of Ku-mediated end joining suppresses mec1Delta lethality by depleting the ribonucleotide reductase inhibitor Sml1 through a pathway controlled by Tel1 kinase and the Mre11 complex



Adaptive expression responses in the Pol-gamma null strain of S. pombe depleted of mitochondrial genome

Chu Z, Li J, Eshaghi M, Karuturi RKM, Lin K, Liu J BMC Genomics. 2007;8:323 BACKGROUND: DNA polymerase gamma(Pol-gamma) has been shown to be essential for maintenance of the mitochondrial genome (mtDNA) in the petite-positive budding yeast Saccharomyces cerevisiae. Budding yeast cells lacking mitochondria exhibit a slow-growing or petite-colony phenotype. Petite strains fail to grow … Continue reading Adaptive expression responses in the Pol-gamma null strain of S. pombe depleted of mitochondrial genome



Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence

Xue C, Liu T, Chen L, Li W, Liu I, Kronstad JW, Seyfang A, Heitman J MBio. 2010 May 18;1(1) Cryptococcus neoformans and Cryptococcus gattii are globally distributed human fungal pathogens and the leading causes of fungal meningitis. Recent studies reveal that myo-inositol is an important factor for fungal sexual reproduction. That C. neoformans can … Continue reading Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence



Beyond Agar: Gel Substrates with Improved Optical Clarity and Drug Efficiency and Reduced Autofluorescence for Microbial Growth Experiments

Jaeger PA, McElfresh C, Wong LR, Ideker T. Appl Environ Microbiol. 2015 Aug 15;81(16):5639-49. doi: 10.1128/AEM.01327-15. Epub 2015 Jun 12. Agar, a seaweed extract, has been the standard support matrix for microbial experiments for over a century. Recent developments in high-throughput genetic screens have created a need to reevaluate the suitability of agar for use … Continue reading Beyond Agar: Gel Substrates with Improved Optical Clarity and Drug Efficiency and Reduced Autofluorescence for Microbial Growth Experiments



Species coexistence in simple microbial communities: unravelling the phenotypic landscape of co-occurring Metschnikowia species in floral nectar

Pozo MI, Herrera CM, Lachance MA, Verstrepen K, Lievens B, Jacquemyn H. Environ Microbiol. 2015 Sep 3. doi: 10.1111/1462-2920.13037. [Epub ahead of print] Identifying the ecological processes that underlie the distribution and abundance of species in microbial communities is a central issue in microbial ecology and evolution. Classical trade-off based niche theories of resource competition … Continue reading Species coexistence in simple microbial communities: unravelling the phenotypic landscape of co-occurring Metschnikowia species in floral nectar