High-throughput screening - Singer Instruments

Create and screen vast microbial libraries at game-changing densities and speed.

ROTOR+ is a precision benchtop robot for easy, ultra-fast manipulation of high-density microbial arrays.

Miniaturise your experiments onto SBS plates containing 96, 384, 1536 or even 6144 colonies per plate to save on consumables.

Over 99% transfer efficiency across a range of model (S. cerevisiae, E. coli,
C. reinhardtii) and non-model organisms – even filamentous fungi.

1 in a million hit? Let ROTOR+ find your needle in a haystack in just one hour.

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2,000+ happy microbiologists and counting.

Bean GJ, Jaeger PA, Bahr S, Ideker T. Development of ultra-high-density screening tools for microbial “omics”. PLoS One. 2014 Jan 21;9(1):e85177. https://doi.10.1371/journal.pone.0085177

OM(G)-ics!

Cloning resistant mutants en mass?
Trey Ideker and colleagues at the University of San Diego (Bean, et al., 2014) successfully used ROTOR to plate a mind blowing 24576 individual colonies on a single plate.
What’s more they achieved equal or better precision than alternative methods, revolutionising high-throughput screening.

What could you achieve?

Over 10 years ago, Dr Jane Usher’s lab took the leap and integrated ROTOR into their workflow. The Usher lab performs high-throughput screening of genome wide gene deletion libraries to identify new gene targets and novel combinatorial therapies.

“We can go from liquid media to solid, solid to solid… we can do mating, we can do replicating… we’re able to do an entire library of SGA screening… it’s a massive workhorse for the entire lab.”

The lab group recently upgraded their ROTOR HDA to a ROTOR+.

“For scalability and high throughput the ROTOR+ has allowed us to phenotype
thousands of strains, which otherwise would not have been possible.”

Professor Joseph Schacherer
Strasbourg University, co-founder of the 1002 Yeast Genomes Project.

New HTS Applications

Explore Essential Genes

Study essential genes. Valenti et al., 2025 used the ROTOR+ to build the Auxin-Inducible Degron (AID) library. This game-changing workflow transforms how labs study lethal mutations and dynamic protein-to-gene networks at scale.

Phage screens

Automated, ultra-high-density pinning of 1,536 phage-host interactions on a single plate (Nair et al., 2024).

Golden Gate: Scaling up interactions

Pin transformants directly into high-density SBS plates. Miniaturise the Golden Gate cloning pipeline to skyrocket library production scale (Koebel et al., 2023).

Population genomics

Researchers at the University of Strasbourg are using yeast to understand the natural genetic and phenotypic diversity of populations globally.

Drug discovery

Map complex genetic interactions, such as synthetic lethality and viability, to expose tumor vulnerabilities and project drug resistance (Srivas et al., 2016; Gu et al., 2017)

Complex trait mapping

Map Quantitative Trait Loci (QTL) and uncover your best commercial traits (Bloom et al., 2015; Jakobson & Jarosz, 2019; Nguyen Ba et al., 2022). Select elite industrial strains with ease.

Human disease mapping

ROTOR+ powers Sentinel Interaction Mapping (SIM) and paralogue assays to screen dozens of human disease-linked variants simultaneously in yeast (Yang et al., 2017; Young et al., 2020).

Want to accelerate your screening with ROTOR+?

Book a 30-minute slot to discuss your workflow with one of our product experts, or ask us anything.

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