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Finding the yeast cell cycle CDK
How we used yeast to find the cornerstone cell cycle CDK regulator Cyclin-dependent kinases (CDKs) are multifunctional enzymes found in our cells which phosphorylate (add phosphate chemical groups) to target proteins [1,2]. Once phosphorylated a target protein’s location, function and stability can be altered which in turn affects the behaviour of the cell. All eukaryotes […]
Read MoreHow to Grow Yeast
Your step-by-step guide 15/03/2018 Introduction Here we will show you some quick easy ways to grow yeast in the lab. Yeast is one of the simplest eukaryotic organisms with which we share a common ancestor (albeit over a billion years ago) meaning yeast cells share many basic properties with our own cells. They also come […]
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Establishment of expression-state boundaries by Rif1 and Taz1 in fission yeast
Read MoreDependency of Heterochromatin Domains on Replication Factors
Read MoreRNA metabolism is the primary target of formamide in vivo
Read MoreRho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast
Read MoreHot spots of recombination in fission yeast: inactivation of the M26 hot spot by deletion of the ade6 promoter and the novel hotspot ura4-aim
Read MoreMolecular analysis of the essential gene for adenylate kinase from the fission yeast Schizosaccharomyces pombe
Read MoreRole of the two type II myosins, Myo2 and Myp2, in cytokinetic actomyosin ring formation and function in fission yeast
Read MoreCytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint
Read MoreFission yeast Pds5 is required for accurate chromosome segregation and for survival after DNA damage or metaphase arrest
Read MoreInvolvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage
Read MoreCid1, a Fission Yeast Protein Required for S-M Checkpoint Control when DNA Polymerase delta or varepsilon Is Inactivated
Read MoreSpatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast
Read MoreGrowth arrest and chromosome instability in aneuploid yeast
Read MoreA critical role for the type V myosin, Myo52, in septum deposition and cell fission during cytokinesis in Schizosaccharomyces pombe
Read MoreRequirement of fission yeast Cid14 in polyadenylation of rRNAs
Read Morebtn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis
Read MoreInactivation of the pre-mRNA cleavage and polyadenylation factor Pfs2 in fission yeast causes lethal cell cycle defects
Read MoreThe meiotic recombination hot spot ura4A in Schizosaccharomyces pombe
Read MoreMcp6, a meiosis-specific coiled-coil protein of Schizosaccharomyces pombe, localizes to the spindle pole body and is required for horsetail movement and recombination
Read MoreContrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast
Read MoreThe Clp1p/Flp1p phosphatase ensures completion of cytokinesis in response to minor perturbation of the cell division machinery in Schizosaccharomyces pombe
Read MoreThe C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit
Read MoreFission yeast cdc31p is a component of the half-bridge and controls SPB duplication
Read MoreTranscriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase
Read MoreMCM-GINS and MCM-MCM interactions in vivo visualised by bimolecular fluorescence complementation in fission yeast
Read MoreMug27 is a meiosis-specific protein kinase that functions in fission yeast meiosis II and sporulation
Read MoreBreak-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition
Read MoreMcp4, a meiotic coiled-coil protein, plays a role in F-actin positioning during Schizosaccharomyces pombe meiosis
Read MoreThe Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities
Read MoreModification of tRNALysUUU by Elongator Is Essential for Efficient Translation of Stress mRNAs
Read MoreAbc3-Mediated Efflux of an Endogenous Digoxin-like Steroidal Glycoside by Magnaporthe oryzae Is Necessary for Host Invasion during Blast Disease. PLoS pathogens
Read MoreGenetic analysis of meiotic recombination in Schizosaccharomyces pombe
Read MoreRegulation of the nuclear poly(A)-binding protein by arginine methylation in fission yeast
Read MoreThe deubiquitinating enzyme Ubp21p of fission yeast stabilizes a mutant form of protein kinase Prp4p
Read MoreFission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation
Read Morespp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p
Read MoreSrp2, an SR protein family member of fission yeast: in vivo characterization of its modular domains
Read MoreA centromere DNA-binding protein from fission yeast affects chromosome segregation and has homology to human CENP-B
Read MoreNuclear export competence of pre-40S subunits in fission yeast requires the ribosomal protein Rps2
Read MoreHigh-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe
Read MoreTls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length
Read MoreIdentification of Genes Affecting the Toxicity of Anti-Cancer Drug Bortezomib by Genome-Wide Screening in S. pombe
Read MoreSignificant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes
Read MoreElimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly
Read MoreYeast Augmented Network Analysis (YANA): a new systems approach to identify therapeutic targets for human genetic diseases
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